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In 2018, Portman starred in the science fiction film Annihilation, based on Jeff VanderMeer's novel. She played a biologist and former soldier who studies a mysterious quarantined zone of mutating organisms. One such lesson, she claims, was to "read the lines off the page" and remembering to breathe. Close states, "You have to maintain a certain openness, and if you don't maintain that, you lose something vital as an actor.